Crisp, Helen;
Tavabie, Oliver;
Enever, Yvanne;
Allen, Richard;
Silverman, Milton;
Acevedo, Juan;
Chauhan, Abhishek;
... Mehta, Gautam; + view all
(2024)
Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK
[version 1; peer review: awaiting peer review].
NIHR Open Research
, 4
, Article 69. 10.3310/nihropenres.13669.1.
Preview |
Text
Mehta_92a40113-a2d0-4662-a250-333989296d49_13669_-_gautam_mehta.pdf Download (1MB) | Preview |
Abstract
Liver disease is a major, and increasing, cause of death in the UK. The UK Chronic Liver Failure network (UK-CLIF) was developed as a multi-stakeholder network with the aim to advance cirrhosis research, with emphasis on geographical areas of high disease prevalence or limited research activity. The process involved network development through dissemination and snowball sampling techniques, with monitoring of network development and connections between participants, developed over two online meetings. Network membership included representatives from patients, carers, clinicians, researchers, R&D professionals, industry representatives, and the third sector. Subsequently, two facilitated in-person workshops were conducted with network participants. World Café methodology and participant dot voting was used to develop areas of priority and consensus in: (i) research infrastructure for cirrhosis clinical trials, (ii) clinical factors affecting research delivery, and (iii) research priorities for future trials. Thematic analysis demonstrated that the need for patient-centric trial materials, a lack of resource for clinicians to participate in research, and variability in the standard of inpatient care for cirrhosis, were barriers for cirrhosis clinical trials. Future activities for UK-CLIF include participation in a process of quality standard setting for inpatient care for cirrhosis, and coordination of a James Lind Alliance Priority Setting Partnership to develop research questions for liver cirrhosis.
| Type: | Article |
|---|---|
| Title: | Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK [version 1; peer review: awaiting peer review] |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3310/nihropenres.13669.1 |
| Publisher version: | http://dx.doi.org/10.3310/nihropenres.13669.1 |
| Language: | English |
| Additional information: | Copyright © Crown copyright, 2024 Crisp H et al. This open access work is licensed under the Open Government Licence v3.0, https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/. |
| Keywords: | Liver cirrhosis, clinical trials, alcohol |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10200688 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
