Ocampo-Godinez, JM;
Kreins, AY;
(2024)
Finding NEMO in the thymus.
The Journal of Experimental Medicine
, 221
(11)
, Article e20241590. 10.1084/jem.20241590.
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Abstract
Rosain et al. (https://doi.org/10.1084/jem.20231152) describe the association between anti-type I interferon autoantibodies and severe viral infections in patients with incontinentia pigmenti and heterozygous loss-of-function NEMO variants, suggesting a role for canonical NF-κB signaling in immune tolerance. The mechanisms behind this selective autoimmunity remain unclear.
| Type: | Article |
|---|---|
| Title: | Finding NEMO in the thymus |
| Location: | United States |
| DOI: | 10.1084/jem.20241590 |
| Publisher version: | http://dx.doi.org/10.1084/jem.20241590 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en |
| Keywords: | I-kappa B Kinase, Humans, Thymus Gland, Incontinentia Pigmenti, Autoantibodies, NF-kappa B, Signal Transduction, Animals, Interferon Type I |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10199417 |
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