Hendrick, Elizabeth;
Jamieson, Alexandra;
Chiesa, Scott;
Hughes, Alun;
Jones, Siana;
(2024)
A short review of application of near-infrared spectroscopy (NIRS) for the assessment of microvascular post-occlusive reactive hyperaemia (PORH) in skeletal muscle.
Frontiers in Physiology
, 15
, Article 1480720. 10.3389/fphys.2024.1480720.
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Abstract
Near-infrared spectroscopy (NIRS) is an optical technique that can be used to non-invasively interrogate haemodynamic changes within skeletal muscle. It can be combined with a short (3–5 min) arterial cuff-occlusion to quantify post-occlusive reactive hyperaemia (PORH). This technique has utility in tracking changes in vascular health in relation to exercise, disease progression or treatment efficacy. However, methods for assessing PORH vary widely and there is little consensus on methodological approaches such as sampling frequency, correction for adipose tissue or the analysis endpoints. The purpose of this review was to: (1) summarise recent advances; (2) compare different methodological approaches and (3) identify current knowledge gaps and future objectives for use of NIRS for vascular assessment. We propose key areas for future work, including optimising occlusion duration and comparing methods of correction for the ischemic stimulus, standardising methods for adjustment of adipose tissue thickness, cross-device comparisons and establishing a standard for minimum sampling rate. Comparisons with alternative methods of capturing PORH or upstream vasodilatory responses would be valuable. Addressing these methodological considerations will aid our understanding of this useful, non-invasive tool for characterising PORH within skeletal muscle and facilitate interpretation of results across studies.
| Type: | Article |
|---|---|
| Title: | A short review of application of near-infrared spectroscopy (NIRS) for the assessment of microvascular post-occlusive reactive hyperaemia (PORH) in skeletal muscle |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphys.2024.1480720 |
| Publisher version: | https://doi.org/10.3389/fphys.2024.1480720 |
| Language: | English |
| Additional information: | Copyright © 2024 Hendrick, Jamieson, Chiesa, Hughes and Jones. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | NIRS (near-infrared spectroscopy), post-occlusive reactive hyperaemia, microvascular, skeletal muscle, methods |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10199366 |
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