Chachlioutaki, K;
Li, X;
Koltsakidis, S;
Abdelhakim, HE;
Bouropoulos, N;
Tzetzis, D;
Karavasili, C;
(2025)
How sugar types and fabrication methods affect palatability in paediatric-friendly oromucosal pullulan films of chlorpromazine hydrochloride.
Carbohydrate Polymers
, 348
(Part A)
, Article 122802. 10.1016/j.carbpol.2024.122802.
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CARBPOL-D-24-04660_R2.pdf - Accepted Version Access restricted to UCL open access staff until 30 September 2025. Download (5MB) |
Abstract
Ensuring children adhere to their prescribed medication can be challenging, particularly when a large number of medicines on the market consist of unpalatable drugs and difficult to swallow dosage forms. Sugar-based oromucosal films are easy to administer dosage forms across all age groups within the paediatric population, as they eliminate the need for swallowing or water intake and can contribute to enhancing palatability and medicine adherence. In the current study, electrospun and 3D printed oromucosal films of chlorpromazine hydrochloride (CHZ), a bitter drug, were developed based on pullulan, a natural polysaccharide, and an array of sweeteners. Their taste masking efficacy was assessed in vitro using an electronic tongue, showing a significant suppression of the bitter taste of CHZ in the presence of sucralose, sucrose and isomalt in the 3D-printed films. In vivo assessment further confirmed that the sugar-based 3D printed films are highly acceptable to volunteers. For the electrospun films, volunteers reported neutral responses for overall acceptability, likely due to their lack of familiarity with this type of formulation. Overall, with improved acceptability and further optimization for taste masking, sugar-based films could serve as a viable alternative to conventional solid oral dosage forms for administering drugs to children.
| Type: | Article |
|---|---|
| Title: | How sugar types and fabrication methods affect palatability in paediatric-friendly oromucosal pullulan films of chlorpromazine hydrochloride |
| DOI: | 10.1016/j.carbpol.2024.122802 |
| Publisher version: | http://dx.doi.org/10.1016/j.carbpol.2024.122802 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Sugar-based films, Paediatric drug delivery, Electrospinning, 3D printing, Swallowing difficulties, Taste masking, E-tongue, Human taste panel |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10198934 |
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