Hannam, Al;
Kankraisri, Phinyada;
Thombare, Karan R;
Meher, Prahallad;
Jean, Alexandre;
Hilton, Stephen T;
Murarka, Sandip;
(2024)
Visible light-mediated difluoromethylation/cyclization in batch and flow: scalable synthesis of CHF<sub>2</sub>-containing benzimidazo- and indolo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-ones.
Chemical Communications
, 60
(61)
pp. 7938-7941.
10.1039/d4cc02557a.
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Abstract
We report here a practical and cost-effective method for the synthesis of CHF2-containing benzimidazo- and indolo[2,1,a]-isoquinolin-6(5H)-ones through a visible light-mediated difluoromethylation/cyclization cascade. The method, which affords functionalized multifused N-heterocyclic scaffolds in moderate to high yields under mild reaction conditions, is also easily scalable using low-cost 3D printed photoflow reactors.
| Type: | Article |
|---|---|
| Title: | Visible light-mediated difluoromethylation/cyclization in batch and flow: scalable synthesis of CHF<sub>2</sub>-containing benzimidazo- and indolo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-ones |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d4cc02557a |
| Publisher version: | http://dx.doi.org/10.1039/d4cc02557a |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10198094 |
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