Aydogdu, Mehmet Onur;
(2024)
Electrosprayed polymeric carriers and their antiviral applications against infectious diseases.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
The concept of infectious diseases has been a significant threat to human progress and survival. Viral infectious diseases affecting the respiratory system have been among the leading causes of mortality and morbidity worldwide for many decades. Consequently, continuous research and development are essential in combating infectious diseases, and the concept of drug delivery emerges as a particularly effective strategy. In this thesis, polymeric carrier particles were produced using the electrospraying technique with a particular focus on combating emerging infectious diseases such as COVID-19. The initial chapters investigate the preparation and analysis of polycaprolactone microparticles and poly(lactic-co-glycolic acid) micro and nanoparticles, emphasising the dynamics and mechanisms of the manufacturing methods, production parameters and their direct effect on the electrospraying behaviour, along with how the cascading effect of all those variables is reflected in the particle size and morphology. The final chapter focuses on creating a polymeric drug delivery system made of Dexamethasone loaded double layered poly(lactic-co-glycolic acid) microparticles against the SARS-CoV-2 virus. This system leverages the coaxial electrospraying technique to produce particles with a core-shell structure, optimised for pulmonary drug delivery and overreaches to an extent in which the outer layer increases contact chances with the viruses and deactivates them with its unique surface properties, while the particle releases Dexamethasone encapsulated within the inner layer in a sustained manner to interfere with virus from binding epithelial cells of the respiratory system.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Electrosprayed polymeric carriers and their antiviral applications against infectious diseases |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10197868 |
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