Altun, Esra;
(2024)
Advanced manufacturing of fibrous surgical sutures using pressurised gyration technology.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
This thesis introduces pressurised gyration technology as a promising approach for manufacturing fibrous surgical sutures. The study comprises pressure spinning of poly(lactic-co-glycolic acid) (PLGA) polymer and its combination with polyethylene oxide (PEO) to improve cost-effectiveness, physicochemical properties, and drug release profiles of the sutures produced. Furthermore, the presented innovation engineers fibrous sutures capable of localised antibacterial delivery, with loaded triclosan (TCS) as an alternative to traditional antibacterial coatings, aiming to enhance patient outcomes and reduce both costs and antibiotic use in surgical site infections (SSI). The model pressure spun suture, with a 285 ± 12 μg/mg TCS loading, exhibited a dynamic drug release profile, starting with an initial burst within 24 hours for early infection protection, followed by a sustained release for prolonged antibacterial activity. This performance surpassed that of commercial sutures, offering superior antibacterial effects lasting up to 21 days until complete degradation. The research also presents a next generation pressurised gyration device, designed to improve upon traditional setups by offering enhanced control over experimental parameters while reducing waste and resource use, thereby being more environmentally responsible. Preliminary studies with PLGA using this gyrator demonstrated a 24% increase in production yield and improved fibre quality with adjustments only in collection distance. The versatility of pressurised gyration technology facilitates the rapid, large scale, and costeffective production of customised fibrous sutures. This approach modernises wound healing, benefiting both public health and the medical device industry.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Advanced manufacturing of fibrous surgical sutures using pressurised gyration technology |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10197209 |
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