Backman, Talia;
Burbano, Hernán A;
Karasov, Talia L;
(2024)
Tradeoffs and constraints on the evolution of tailocins.
Trends in Microbiology
10.1016/j.tim.2024.04.001.
(In press).
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Abstract
Phage tail-like bacteriocins (tailocins) are protein complexes produced by bacteria with the potential to kill their neighbors. Widespread throughout Gram-negative bacteria, tailocins exhibit extreme specificity in their targets, largely killing closely related strains. Despite their presence in diverse bacteria, the impact of these competitive weapons on the surrounding microbiota is largely unknown. Recent studies revealed the rapid evolution and genetic diversity of tailocins in microbial communities and suggest that there are constraints on the evolution of specificity and resistance. Given the precision of their targeted killing and the ease of engineering new specificities, understanding the evolution and ecological impact of tailocins may enable the design of promising candidates for novel targeted antibiotics.
| Type: | Article |
|---|---|
| Title: | Tradeoffs and constraints on the evolution of tailocins |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tim.2024.04.001 |
| Publisher version: | https://doi.org/10.1016/j.tim.2024.04.001 |
| Language: | English |
| Additional information: | © 2024 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | bacterial competition, tailocin, microbiome evolution, tradeoffs |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10196962 |
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