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Pyroptosis in liver failure: A twisted firestarter

Mehta, Gautam; Jalan, Rajiv; (2025) Pyroptosis in liver failure: A twisted firestarter. Journal of Hepatology , 82 (2) e91-e92. 10.1016/j.jhep.2024.08.023. Green open access

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Abstract

We read with great interest the review article by Taru and colleagues, focusing on the role of inflammasomes in chronic liver disease.1 The authors have produced a thorough outline of inflammasome biology as well as an overview of potential therapeutic strategies in liver disease. We would like to contribute additional perspectives regarding pyroptosis-directed therapies in decompensated cirrhosis and acute-on-chronic liver failure (ACLF).

Type: Article
Title: Pyroptosis in liver failure: A twisted firestarter
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhep.2024.08.023
Publisher version: https://doi.org/10.1016/j.jhep.2024.08.023
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: acute-on-chronic liver failure, cirrhosis, inflammasome, pyroptosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10196653
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