Chan, Victor TT;
Ran, An Ran;
Wagner, Siegfried K;
Hui, Herbert YH;
Hu, Xiaoyan;
Ko, Ho;
Fekrat, Sharon;
... Cheung, Carol Y; + view all
(2024)
Value Proposition of Retinal Imaging in Alzheimer's Disease Screening: A Review of Eight Evolving Trends.
Progress in Retinal and Eye Research
, 103
, Article 101290. 10.1016/j.preteyeres.2024.101290.
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Abstract
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal fluid testing), but these are limited by their high cost, invasiveness, and lack of expertise. Retinal imaging exhibits potential in AD screening and risk stratification, as the retina provides a platform for the optical visualization of the central nervous system in vivo, with vascular and neuronal changes that mirror brain pathology. Given the paradigm shift brought by advances in artificial intelligence and the emergence of disease-modifying therapies, this article aims to summarize and review the current literature to highlight 8 trends in an evolving landscape regarding the role and potential value of retinal imaging in AD screening.
| Type: | Article |
|---|---|
| Title: | Value Proposition of Retinal Imaging in Alzheimer's Disease Screening: A Review of Eight Evolving Trends |
| Location: | England |
| DOI: | 10.1016/j.preteyeres.2024.101290 |
| Publisher version: | http://dx.doi.org/10.1016/j.preteyeres.2024.101290 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10196326 |
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