Bettinazzi, Stefano;
Liang, Jane;
Rodriguez, Enrique;
Bonneau, Marion;
Holt, Ruben;
Whitehead, Ben;
Dowling, Damian;
... Camus, M Florencia; + view all
(2024)
Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural Drosophila populations.
Evolution Letters
10.1093/evlett/qrae043.
(In press).
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Abstract
Mitochondrial function depends on the effective interactions between proteins and RNA encoded by the mitochondrial and nuclear genomes. Evidence suggests that both genomes respond to thermal selection and promote adaptation. However, the contribution of their epistatic interactions to life history phenotypes in the wild remains elusive. We investigated the evolutionary implications of mitonuclear interactions in a real-world scenario that sees populations adapted to different environments, altering their geographical distribution while experiencing flow and admixture. We created a Drosophila melanogaster panel with replicate native populations from the ends of the Australian east-coast cline, into which we substituted the mtDNA haplotypes that were either predominant or rare at each cline-end, thus creating putatively mitonuclear matched and mismatched populations. Our results suggest that mismatching may impact phenotype, with populations harboring the rarer mtDNA haplotype suffering a trade-off between aerobic capacity and key fitness aspects such as reproduction, growth, and survival. We discuss the significance of mitonuclear interactions as modulators of life history phenotypes in the context of future adaptation and population persistence.
| Type: | Article |
|---|---|
| Title: | Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural Drosophila populations |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/evlett/qrae043 |
| Publisher version: | https://doi.org/10.1093/evlett/qrae043 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE) and European Society for Evolutionary Biology (ESEN). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | mitochondria, mitonuclear interactions, Drosophila melanogaster, OXPHOS, fitness, local adaptation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10195799 |
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