Zhu, Christiane;
Herbst, Susanne;
Lewis, Patrick A;
(2023)
Leucine-rich repeat kinase 2 at a glance.
Journal of Cell Science
, 136
(17)
, Article jcs259724. 10.1242/jcs.259724.
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Abstract
Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual guanosine triphosphatase (GTPase) and kinase enzymatic activities, providing this protein with the capacity to regulate a multitude of signalling pathways and act as a key mediator of diverse cellular processes. Much of the interest in LRRK2 derives from mutations in the LRRK2 gene being the most common genetic cause of Parkinson’s disease, and from the association of the LRRK2 locus with a number of other human diseases, including inflammatory bowel disease. Therefore, the LRRK2 research field has focused on the link between LRRK2 and pathology, with the aim of uncovering the underlying mechanisms and, ultimately, finding novel therapies and treatments to combat them. From the biochemical and cellular functions of LRRK2, to its relevance to distinct disease mechanisms, this Cell Science at a Glance article and the accompanying poster deliver a snapshot of our current understanding of LRRK2 function, dysfunction and links to disease.
| Type: | Article |
|---|---|
| Title: | Leucine-rich repeat kinase 2 at a glance |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/jcs.259724 |
| Publisher version: | http://dx.doi.org/10.1242/jcs.259724 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, Leucine-rich repeat kinase 2, GTPase, Kinase, Structure, Function, Cellular processes, Parkinson's disease, SYNAPTIC VESICLE ENDOCYTOSIS, DISEASE-ASSOCIATED PROTEIN, PARKINSONS-DISEASE, LRRK2 KINASE, LEUCINE-RICH-REPEAT-KINASE-2 LRRK2, G2019S MUTATIONS, 14-3-3 BINDING, RIP KINASES, ROC DOMAIN, GENE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10194396 |
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