Ripoll, M;
Lerma-Escalera, JA;
Morones-Ramírez, JR;
Rios-Solis, L;
Betancor, L;
(2023)
New perspectives into Gluconobacter-catalysed biotransformations.
Biotechnology Advances
, 65
, Article 108127. 10.1016/j.biotechadv.2023.108127.
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Abstract
Different from other aerobic microorganisms that oxidise carbon sources to water and carbon dioxide, Gluconobacter catalyses the incomplete oxidation of various substrates with regio- and stereoselectivity. This ability, as well as its capacity to release the resulting products into the reaction media, place Gluconobacter as a privileged member of a non-model microorganism class that may boost industrial biotechnology. Knowledge of new technologies applied to Gluconobacter has been piling up in recent years. Advancements in its genetic modification, application of immobilisation tools and careful designs of the transformations, have improved productivities and stabilities of Gluconobacter strains or enabled new bioconversions for the production of valuable marketable chemicals. In this work, the latest advancements applied to Gluconobacter-catalysed biotransformations are summarised with a special focus on recent available tools to improve them. From genetic and metabolic engineering to bioreactor design, the most recent works on the topic are analysed in depth to provide a comprehensive resource not only for scientists and technologists working on/with Gluconobacter, but for the general biotechnologist.
| Type: | Article |
|---|---|
| Title: | New perspectives into Gluconobacter-catalysed biotransformations |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biotechadv.2023.108127 |
| Publisher version: | http://dx.doi.org/10.1016/j.biotechadv.2023.108127 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Gluconobacter, Biotransformations, Whole-cell immobilisation, Genetic engineering, Industrial biotechnology, Process intensification, Green chemistry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10194384 |
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