Singla, Pankaj;
Broughton, Thomas;
Sullivan, Mark V;
Garg, Saweta;
Berlinguer-Palmini, Rolando;
Gupta, Priyanka;
Smith, Katie;
... Peeters, Marloes; + view all
(2024)
Double Imprinted Nanoparticles for Sequential Membrane-to-Nuclear Drug Delivery.
Advanced Science
, Article 2309976. 10.1002/advs.202309976.
(In press).
Preview |
Text
Velliou_Advanced Science - 2024 - Singla - Double Imprinted Nanoparticles for Sequential Membrane‐to‐Nuclear Drug Delivery.pdf Download (8MB) | Preview |
Abstract
Efficient and site-specific delivery of therapeutics drugs remains a critical challenge in cancer treatment. Traditional drug nanocarriers such as antibody-drug conjugates are not generally accessible due to their high cost and can lead to serious side effects including life-threatening allergic reactions. Here, these problems are overcome via the engineering of supramolecular agents that are manufactured with an innovative double imprinting approach. The developed molecularly imprinted nanoparticles (nanoMIPs) are targeted towards a linear epitope of estrogen receptor alfa (ERα) and loaded with the chemotherapeutic drug doxorubicin. These nanoMIPs are cost-effective and rival the affinity of commercial antibodies for ERα. Upon specific binding of the materials to ERα, which is overexpressed in most breast cancer (BCs), nuclear drug delivery is achieved via receptor-mediated endocytosis. Consequentially, significantly enhanced cytoxicity is elicited in BC cell lines overexpressing ERα, paving the way for precision treatment of BC. Proof-of-concept for the clinical use of the nanoMIPs is provided through evaluating their dug efficacy in sophisticated 3D scaffolds, which capture the complexity of the tumour microenvironment in vivo without requiring animal models. Thus, these findings highlight the potential of nanoMIPs as a promising class of novel drug compounds for use in cancer treatment.
| Type: | Article |
|---|---|
| Title: | Double Imprinted Nanoparticles for Sequential Membrane-to-Nuclear Drug Delivery |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/advs.202309976 |
| Publisher version: | https://doi.org/10.1002/advs.202309976 |
| Language: | English |
| Additional information: | Copyright © 2024 The Author(s). Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | imprinted nanoparticles, targeted drug delivery, breast cancer, chemotherapy, precision nanomedicine, biomimetic 3D scaffolds |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10193891 |
Archive Staff Only
 |
View Item |
