Giampazolias, E;
Costa, MPD;
Lam, KC;
Lim, KHJ;
Cardoso, A;
Piot, C;
Chakravarty, P;
... Sousa, CRE; + view all
(2024)
Vitamin D regulates microbiome-dependent cancer immunity.
Science
, 384
(6694)
pp. 428-437.
10.1126/science.adh7954.
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Abstract
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis, which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.
| Type: | Article |
|---|---|
| Title: | Vitamin D regulates microbiome-dependent cancer immunity |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.adh7954 |
| Publisher version: | http://dx.doi.org/10.1126/science.adh7954 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Animals, Female, Humans, Male, Mice, Bacteroides fragilis, Gastrointestinal Microbiome, Immune Checkpoint Inhibitors, Immunotherapy, Intestinal Mucosa, Mice, Inbred C57BL, Neoplasms, Vitamin D, Diet, Cell Line, Tumor, Calcifediol, Vitamin D-Binding Protein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10193857 |
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