Almossawi, Ofran;
Friend, Amanda;
Palla, Luigi;
Feltbower, Richard;
Sardo-Infiri, Sofia;
O’Brien, Scott;
Harron, Katie;
... De Stavola, Bianca; + view all
(2022)
Is there a sex difference in mortality rates in Paediatric Intensive Care Units: A Systematic Review.
MedRxiv: Cold Spring Harbor, NY, USA.
Preview |
Text
Is there a sex difference in mortality rates in Paediatric Intensive Care Units A Systematic Review.pdf - Other Download (1MB) | Preview |
Abstract
Introduction: Mortality rates in infancy and childhood are lower in females than males. However, for children admitted to Paediatric Intensive Care Units (PICU), mortality has been reported to be lower in males, although males have higher admission rates. This female mortality excess for the subgroup of children admitted in intensive care is not well understood. To address this, we carried out a systematic literature review to summarise the available evidence. Our review studies the differences in mortality between males and females aged 0 to <18 years, while in a PICU, to examine whether there was a clear difference (in either direction) in PICU mortality between the two sexes, and, if present, to describe the magnitude and direction of this difference. / Methods and analysis: Any studies that directly or indirectly reported the rates of mortality in children admitted to intensive care by sex were eligible for inclusion. The search strings were based on terms related to the population (those admitted into a paediatric intensive care unit), the exposure (sex), and the outcome (mortality). We used the search databases MEDLINE, Embase, and Web of Science as these cover relevant clinical publications. We assessed the reliability of included studies using a modified version of the risk of bias in observational studies of exposures (ROBINS-E) tool. We considered estimating a pooled effect if there were at least three studies with similar populations, periods of follow-up while in PICU, and adjustment variables. / Results: We identified 124 studies of which 114 reported counts of deaths by males and females which gave a population of 278,274 children for analysis, involving 121,800 (44%) females and 156,474 males (56%). The number of deaths and mortality rate for females were 5,614 (4.61%), and for males 6,828 (4.36%). In the pooled analysis, the odds ratio of female to male mortality was 1.06 [1.01 to 1.11] for the fixed effect model, and 1.10 [1.00 to 1.21] for the random effects model. / Conclusion: Overall, males have a higher admission rate to PCU, and a lower overall mortality in PICU. / Systematic review registration: PROSPERO database reference number CRD42020203009.
| Type: | Working / discussion paper |
|---|---|
| Title: | Is there a sex difference in mortality rates in Paediatric Intensive Care Units: A Systematic Review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1101/2022.05.27.22275455 |
| Publisher version: | https://doi.org/10.1101/2022.05.27.22275455 |
| Language: | English |
| Additional information: | The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Child; Critical Care; Paediatric Intensive Care; Intensive Care; Mortality; Sex Differences |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10193627 |
Archive Staff Only
 |
View Item |
