Mukhopadhyay, Upasana;
Mandal, Tithi;
Chakraborty, Madhura;
Sinha, Bidisha;
(2024)
The Plasma Membrane and Mechanoregulation in Cells.
ACS Omega
, 9
(20)
pp. 21780-21797.
10.1021/acsomega.4c01962.
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Abstract
Cells inhabit a mechanical microenvironment that they continuously sense and adapt to. The plasma membrane (PM), serving as the boundary of the cell, plays a pivotal role in this process of adaptation. In this Review, we begin by examining well-studied processes where mechanoregulation proves significant. Specifically, we highlight examples from the immune system and stem cells, besides discussing processes involving fibroblasts and other cell types. Subsequently, we discuss the common molecular players that facilitate the sensing of the mechanical signal and transform it into a chemical response covering integrins YAP/TAZ and Piezo. We then review how this understanding of molecular elements is leveraged in drug discovery and tissue engineering alongside a discussion of the methodologies used to measure mechanical properties. Focusing on the processes of endocytosis, we discuss how cells may respond to altered membrane mechanics using endo- and exocytosis. Through the process of depleting/adding the membrane area, these could also impact membrane mechanics. We compare pathways from studies illustrating the involvement of endocytosis in mechanoregulation, including clathrin-mediated endocytosis (CME) and the CLIC/GEEC (CG) pathway as central examples. Lastly, we review studies on cell–cell fusion during myogenesis, the mechanical integrity of muscle fibers, and the reported and anticipated roles of various molecular players and processes like endocytosis, thereby emphasizing the significance of mechanoregulation at the PM.
| Type: | Article |
|---|---|
| Title: | The Plasma Membrane and Mechanoregulation in Cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsomega.4c01962 |
| Publisher version: | http://dx.doi.org/10.1021/acsomega.4c01962 |
| Language: | English |
| Additional information: | This publication is licensed under CC-BY-NC-ND 4.0. See: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, CLATHRIN-MEDIATED ENDOCYTOSIS, ATOMIC-FORCE MICROSCOPY, DIFFERENTIAL REQUIREMENTS, MICROPIPETTE ASPIRATION, EXTRACELLULAR-MATRIX, PIT-FORMATION, LIPID RAFTS, TENSION, ACTIN, MICROENVIRONMENT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10193028 |
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