Zhang, L; Xu, Y; Baier, G; Liu, Y; Li, B; (2024) Exploring the dynamical transitions on an epileptic hippocampal network model and its modulation strategy based on transcranial magneto-acoustical stimulation. Nonlinear Dynamics , 112 pp. 9495-9513. 10.1007/s11071-024-09476-0.

Text MS_20240302_Zhang2024.pdf - Accepted Version Access restricted to UCL open access staff until 19 April 2025. Download (1MB)

Abstract

The mechanisms of network and transition dynamics of epileptiform activity remain unclear. In general, the transitions of epileptiform discharges comprise slow interictal discharges, ictal discharges and postictal depression. Studies have indicated that network properties and the inherent parameters of neuronal models have great impacts on the transitions. Recently, a novel neuromodulation technique, transcranial magneto-acoustical stimulation (TMAS), has been tested for its efficiency experimentally and computationally. In this paper, we establish a biophysical computational network model of an ictogenic hippocampus area to investigate the underlying transitions mechanisms and reveal neuromodulation mechanisms combined with TMAS. Results demonstrate that long distance connections caused by increased connection probability and the number of nearest-neighbour edges make the network more random and focused. The cooperation of network topological structure and neuronal parameters including ion concentration and inherent external input of neurons could induce epileptic transitions. Moreover, the focused ultrasound transducer has the ability to launch and focus the transcranial ultrasound wave to the hippocampal area in the depth of the three-layer tissue. By coupling with a static magnetic field, the proposed modulated induced TMAS currents can terminate epileptiform activity but consumes more energy by regulating magnetic strength. However, changing modulation frequency was unable to fully suppress seizures. These computational results offer an explanation of the mechanisms of neurodynamics of epileptiform discharges and its neuromodulation by TMAS.

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