Hsu, Warrington WQ;
Zhang, Xiaowen;
Sing, Chor-Wing;
Tan, Kathryn CB;
Wong, Ian Chi-Kei;
Lau, Wallis CY;
Cheung, Ching-Lung;
(2024)
Unveiling unique clinical phenotypes of hip fracture patients and the temporal association with cardiovascular events.
Nature Communications
, 15
(1)
, Article 4353. 10.1038/s41467-024-48713-3.
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Abstract
Cardiovascular events are the leading cause of death among hip fracture patients. This study aims to identify subphenotypes of hip fracture patients and investigate their association with incident cardiovascular events, all-cause mortality, and health service utilisation in Hong Kong and the United Kingdom populations. By the latent class analysis, we show three distinct clusters in the Hong Kong cohort (n = 78,417): Cluster 1 has cerebrovascular and hypertensive diseases, hyperlipidemia, and diabetes; Cluster 2 has congestive heart failure; Cluster 3 consists of relatively healthy patients. Compared to Cluster 3, higher risks of major adverse cardiovascular events are observed in Cluster 1 (hazard ratio 1.97, 95% CI 1.83 to 2.12) and Cluster 2 (hazard ratio 4.06, 95% CI 3.78 to 4.35). Clusters 1 and 2 are also associated with a higher risk of mortality, more unplanned accident and emergency visits and longer hospital stays. Self-controlled case series analysis shows a significantly elevated risk of major adverse cardiovascular events within 60 days post-hip fracture. Similar associations are observed in the United Kingdom cohort (n = 27,948). Pre-existing heart failure is identified as a unique subphenotype associated with poor prognosis after hip fractures.
Type: | Article |
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Title: | Unveiling unique clinical phenotypes of hip fracture patients and the temporal association with cardiovascular events |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1038/s41467-024-48713-3 |
Publisher version: | http://dx.doi.org/10.1038/s41467-024-48713-3 |
Language: | English |
Additional information: | © 2024 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Bone, Endocrine system and metabolic diseases, Heart failure |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
URI: | https://discovery.ucl.ac.uk/id/eprint/10192747 |
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