Zhang, Shen;
Simard, Mikaël;
Lapointe, Andréanne;
Filion, Édith;
Campeau, Marie-Pierre;
Vu, Thi Trinh Thuc;
Roberge, David;
... Bahig, Houda; + view all
(2024)
Evaluation of radiation dose effect on lung function using iodine maps derived from dual-energy computed tomography.
International Journal of Radiation Oncology*Biology*Physics
10.1016/j.ijrobp.2024.04.069.
(In press).
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1-s2.0-S0360301624006096-main.pdf - Accepted Version Access restricted to UCL open access staff until 3 May 2025. Download (1MB) |
Abstract
PURPOSE: There is interest in using dual-energy computed tomography (DECT) to evaluate organ function before and after radiotherapy. The purpose of this study (trial identifier: XXXX) is to assess longitudinal changes in lung perfusion using iodine maps derived from DECT in lung cancer patients treated with conventional or stereotactic radiotherapy (RT). METHODS: For 48 prospectively enrolled lung cancer patients, a contrast-enhanced DECT using a dual-source CT simulator was acquired pre-treatment and at 6 and 12 months post-treatment. Pulmonary functions tests (PFT) were obtained at baseline and at 6 and 12 months post-treatment. Iodine maps were extracted from the DECT images using a previously described 2-material decomposition framework. Longitudinal iodine maps were normalized using a reference region defined as all voxels with perfusion in the top 10% outside of the 5 Gy isodose volume. Normalized functional responses (NFR) were calculated for three dose ranges: <5 Gy, 5-20 Gy and >20 Gy. Mixed model analysis was used to assess the correlation between dose metrics and NFR. Pearson correlation was used to assess if NFR are correlated with PFT changes. RESULTS: Out of the 48 patients, 21 (44%) were treated with stereotactic body radiation therapy (SBRT) and 27 (56%) were treated with conventionally fractionated IMRT. 31 out of these 48 patients were ultimately included in data analysis. It was found that NFR is linearly correlated with dose (p < 0.001) for both groups. The number of months elapsed post-RT is also found to correlate with NFR (p = 0.029), although this correlation was not observed for the SBRT subgroup. The NFR is not found to correlate with PFT changes. CONCLUSION: DECT derived iodine maps are a promising method for detailed anatomic evaluation of radiation effect on lung function, including potentially subclinical changes.
| Type: | Article |
|---|---|
| Title: | Evaluation of radiation dose effect on lung function using iodine maps derived from dual-energy computed tomography |
| Location: | United States |
| DOI: | 10.1016/j.ijrobp.2024.04.069 |
| Publisher version: | https://doi.org/10.1016/j.ijrobp.2024.04.069 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cancer, Lung Cancer, dual energy computed tomography, functional imaging, radiotherapy, toxicities |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10192159 |
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