Hicks, Roxana M;
Ji, Xunda;
Zou, Yihua;
Sultana, Sadia;
Rashid, Riffat;
Sherief, Sadik T;
Cassoux, Nathalie;
... Stacey, Andrew W; + view all
(2024)
Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma.
Investigative Ophthalmology & Visual Science
, 65
(4)
, Article 39. 10.1167/iovs.65.4.39.
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Abstract
PURPOSE: Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb. METHODS: A multinational, longitudinal cohort study was conducted with patients from 11 centers in 10 countries who presented with treatment naïve Rb from January to December 2019. Variables of interest included age, sex, and size characteristics at birth and at time of presentation, as well as germline mutation status. After Bonferroni correction, results were statistically significant if the P value was less than 0.005. RESULTS: We enrolled 696 patients, with 253 analyzed after exclusion criteria applied. Between somatic (n = 39) and heritable (n = 214) Rb cohorts, with males and females analyzed separately, there was no significant difference in birth weight percentile, weight percentile at time of diagnosis, length percentile at time of diagnosis, weight-for-length percentile at time of diagnosis, or change of weight percentile from birth to time of diagnosis. Patients with heritable Rb had a smaller mean weight percentile at birth and smaller mean weight and length percentiles at time of diagnosis with Rb, although this difference was not statistically significant. All cohorts experienced a slight negative change of weight percentile from birth to time of diagnosis. No cohort mean percentiles met criteria for failure to thrive, defined as less than the 5th percentile. CONCLUSIONS: Children with Rb seem to have normal birth and childhood growth patterns. There is no definitive evidence that somatic or heritable Rb has a biological or environmental impact on childhood growth parameters.
| Type: | Article |
|---|---|
| Title: | Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1167/iovs.65.4.39 |
| Publisher version: | https://doi.org/10.1167%2Fiovs.65.4.39 |
| Language: | English |
| Additional information: | © The Authors 2024. Original content in this paper is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | retinoblastoma, failure to thrive, germline, childhood growth, growth parametersent, Germ-Line Mutation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10191569 |
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