Dymerska, Barbara;
Cardoso, Pedro;
Mahr, Nina;
Matt, Eva;
Fischmeister, Florian;
Beisteiner, Roland;
Trattnig, Siegfried;
(2016)
Investigating the Impact of Temporal Signal Fluctuations and Local Effective Echo Times on Indices of BOLD Sensitivity in Healthy Subjects and Tumor Patients at 7T.
Presented at: ISMRM 24tj Annual Meeting, Singapore, Singapore.
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Abstract
Temporal signal fluctuations (tSNR) and local effective echo time (TEₗₒ꜀ₐₗ) are explored and their influence on BOLD sensitivity is investigated at 7T for healthy subjects and tumor patients, where prominent spatial variations in those two measures are expected. We show that tSNR may indicate sufficient sensitivity to detect activation but that BOLD sensitivity may be dramatically reduced by changes in TEₗₒ꜀ₐₗ close to pathologies and vital brain functions (motor, speech, auditory). Neglecting local TE variations can thus lead to false negative results in clinical fMRI. We thus suggest a new BOLD sensitivity metric based on TEₗₒ꜀ₐₗ∙tSNR.
| Type: | Conference item (Presentation) |
|---|---|
| Title: | Investigating the Impact of Temporal Signal Fluctuations and Local Effective Echo Times on Indices of BOLD Sensitivity in Healthy Subjects and Tumor Patients at 7T |
| Event: | ISMRM 24tj Annual Meeting |
| Location: | Singapore, Singapore |
| Dates: | 07 May - 13 May 2016 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://cds.ismrm.org/protected/16MProceedings/PDF... |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10190795 |
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