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A Feasibility Prototype of a Low-dose Stationary Tomographic Molecular Breast Imaging Camera Using 3D Position Sensitive CZT Detectors

Cherlin, A; Wirth, A; Erlandsson, K; Baistow, I; Thielemans, K; Hutton, BF; (2024) A Feasibility Prototype of a Low-dose Stationary Tomographic Molecular Breast Imaging Camera Using 3D Position Sensitive CZT Detectors. In: Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2022. (pp. pp. 1-4). Institute of Electrical and Electronics Engineers (IEEE) Green open access

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Abstract

A novel Molecular Breast Imaging system (MBI) is being developed by Kromek and University College London. MBI systems have been shown to provide excellent results in patients with dense breasts, but higher than mammography patient dose and long imaging time of 40 min impede their wide adoption. The design is based on a pair of opposing CZT detector arrays and high-density multi-pinhole (MPH) collimators. The new system combines superior energy and position resolution and depth of interaction (DOI) sensing of CZT detectors, wide range angular sampling of MPH collimators and novel de-multiplexing image reconstruction techniques to deliver tomographic images with stationary detectors. The new system is expected to mitigate the MBI drawbacks without compromising diagnostic content.Following the initial evaluation, a new feasibility prototype using upgraded ASIC and new front-end electronics was designed, built, and characterised. New image reconstruction and de-noising algorithms were developed on simulated data to improve the Contrast-to-Noise (CNR) ratio and reduce the fluctuations in the correlated background noise associated with MPH image reconstruction. The collimator geometry was further optimised by including non-local means noise filtering which increased the CNR by almost a factor of 3. The current results indicate that we can achieve the dose reduction to the mammography level, reduce the minimum size of detected lesions to about 6 mm and have an additional potential for reduction of the measurement time.

Type: Proceedings paper
Title: A Feasibility Prototype of a Low-dose Stationary Tomographic Molecular Breast Imaging Camera Using 3D Position Sensitive CZT Detectors
Event: 2022 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Location: Italy
Dates: 5th-12th November 2022
ISBN-13: 978-1-6654-8872-3
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/NSS/MIC44845.2022.10398981
Publisher version: http://dx.doi.org/10.1109/nss/mic44845.2022.103989...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10189822
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