Harris, Julia J;
Burdakov, Denis;
(2024)
A role for MCH neuron firing in modulating hippocampal plasticity threshold.
Peptides
, 172
, Article 171128. 10.1016/j.peptides.2023.171128.
Preview |
PDF
1-s2.0-S0196978123001936-main.pdf - Other Download (3MB) | Preview |
Abstract
It has been revealed that hypothalamic neurons containing the peptide, melanin-concentrating hormone (MCH) can influence learning [1] and memory formation [2], but the cellular mechanisms by which they perform this function are not well understood. Here, we examine the role of MCH neural input to the hippocampus, and show in vitro that optogenetically increasing MCH axon activity facilitates hippocampal plasticity by lowering the threshold for synaptic potentiation. These results align with increasing evidence that MCH neurons play a regulatory role in learning, and reveal that this could be achieved by modulating plasticity thresholds in the hippocampus.
| Type: | Article |
|---|---|
| Title: | A role for MCH neuron firing in modulating hippocampal plasticity threshold |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.peptides.2023.171128 |
| Publisher version: | http://dx.doi.org/10.1016/j.peptides.2023.171128 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Melanin-concentrating hormone, MCH, Hippocampus, Synaptic plasticity, Optogenetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10189352 |
Archive Staff Only
 |
View Item |
