Fittall, MW;
Brewer, M;
de Boisanger, J;
Kviat, L;
Babiker, A;
Taylor, H;
Saran, F;
... Rosenfelder, N; + view all
(2024)
Predicting Survival with Brain Metastases in the Stereotactic Radiosurgery Era: are Existing Prognostic Scores Still Relevant? Or Can we do Better?
Clinical Oncology
10.1016/j.clon.2024.01.037.
(In press).
Preview |
Text
CO_Brain_mets_2024.pdf - Published Version Download (2MB) | Preview |
Abstract
Predicting survival is essential to tailoring treatment for patients diagnosed with brain metastases. We have evaluated the performance of widely used, validated prognostic scoring systems (Graded Prognostic Assessment and diagnosis-specific Graded Prognostic Assessment) in over 1000 'real-world' patients treated with stereotactic radiosurgery to the brain, selected according to National Health Service commissioning criteria. Survival outcomes from our dataset were consistent with those predicted by the prognostic systems, but with certain cancer subtypes showing a significantly better survival than predicted. Although performance status remains the simplest tool for prediction, total brain tumour volume emerges as an independent prognostic factor, and a new, improved, prognostic scoring system incorporating this has been developed.
| Type: | Article |
|---|---|
| Title: | Predicting Survival with Brain Metastases in the Stereotactic Radiosurgery Era: are Existing Prognostic Scores Still Relevant? Or Can we do Better? |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clon.2024.01.037 |
| Publisher version: | http://dx.doi.org/10.1016/j.clon.2024.01.037 |
| Language: | English |
| Additional information: | Crown Copyright © 2024 Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Brain metastases, prognostic score, radiosurgery, stereotactic, survival |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10188358 |
Archive Staff Only
 |
View Item |
