Häge, Alexander;
Man, Kenneth KC;
Inglis, Sarah K;
Buitelaar, Jan;
Carucci, Sara;
Danckaerts, Marina;
Dittmann, Ralf W;
... Banaschewski, Tobias; + view all
(2024)
Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study.
Journal of Attention Disorders
10.1177/10870547241232337.
(In press).
Preview |
Text
Man_ADDUCE_Sleep_manuscr_31082023csreview_clean.pdf Download (252kB) | Preview |
Abstract
Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited. Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study. Participants were recruited into three groups: ADHD patients intending to start MPH-treatment (MPH-group), those not intending to use ADHD-medication (no-MPH-group), and a non-ADHD control-group. Sleep problems were assessed with the Children’s-Sleep-Habits-Questionnaire (CSHQ). Results: 1,410 participants were enrolled. Baseline mean CSHQ-total-sleep-scores could be considered clinically significant for the MPH-group and the no-MPH-group, but not for controls. The only group to show a significant increase in any aspect of sleep from baseline to 24-months was the control-group. Comparing the MPH- to the no-MPH-group no differences in total-sleep-score changes were found. Conclusion: Our findings support that sleep-problems are common in ADHD, but don’t suggest significant negative long-term effects of MPH on sleep.
Archive Staff Only
 |
View Item |
