Khurana, Dolphee;
Suresh, Ankitha;
Nayak, Raghavendra;
Shetty, Manjunath;
Sarda, Rohit Kumar;
Knowles, Jonathan C;
Kim, Hae-Won;
... Singh, Bhisham Narayan; + view all
(2024)
Biosubstitutes for dural closure: Unveiling research, application, and future prospects of dura mater alternatives.
Journal of Tissue Engineering
, 15
pp. 1-26.
10.1177/20417314241228118.
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Abstract
The dura mater, as the crucial outermost protective layer of the meninges, plays a vital role in safeguarding the underlying brain tissue. Neurosurgeons face significant challenges in dealing with trauma or large defects in the dura mater, as they must address the potential complications, such as wound infections, pseudomeningocele formation, cerebrospinal fluid leakage, and cerebral herniation. Therefore, the development of dural substitutes for repairing or reconstructing the damaged dura mater holds clinical significance. In this review we highlight the progress in the development of dural substitutes, encompassing autologous, allogeneic, and xenogeneic replacements, as well as the polymeric-based dural substitutes fabricated through various scaffolding techniques. In particular, we explore the development of composite materials that exhibit improved physical and biological properties for advanced dural substitutes. Furthermore, we address the challenges and prospects associated with developing clinically relevant alternatives to the dura mater.
| Type: | Article |
|---|---|
| Title: | Biosubstitutes for dural closure: Unveiling research, application, and future prospects of dura mater alternatives |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/20417314241228118 |
| Publisher version: | http://dx.doi.org/10.1177/20417314241228118 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2024. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Dura mater; dural substitutes; brain trauma and injury; polymeric scaffolds; composites; tissue engineering |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187934 |
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