Jungbauer, Alois;
Satzer, Peter;
Duerauer, Astrid;
Azevedo, Ana;
Aires-Barros, Raquel;
Nilsson, Bernt;
Farid, Suzy;
... Marcelo Fernandez Lahore, Hector; + view all
(2024)
Continuous downstream processing.
Separation and Purification Technology
, 338
, Article 126439. 10.1016/j.seppur.2024.126439.
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Abstract
The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioprocesses and production facilities. In the biopharmaceutical industry, two extreme production scenarios are applied: a fully disposable factory with the characteristics of full flexibility and speed, or a fixed large-scale plant with high capacity. Forward-looking solutions and ideas will be discussed how to combine new processes and environmental friendliness for the benefit of the patient, security of supply and profitability. The concept will be extended to large scale production of proteins for food and non-pharma applications, e.g., in material science and a roadmap towards a future plant will be laid out.
| Type: | Article |
|---|---|
| Title: | Continuous downstream processing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.seppur.2024.126439 |
| Publisher version: | http://dx.doi.org/10.1016/j.seppur.2024.126439 |
| Language: | English |
| Additional information: | Copyright © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Continuous integrated biomanufacturing; Scale down; Microfluidics; Economics; Environmental footprint |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187498 |
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