Oswal, Ashwini;
Abdi-Sargezeh, Bahman;
Sharma, Abhinav;
Ozkurt, Tolga Esat;
Taulu, Samu;
Sarangmat, Nagaraja;
Green, Alexander L;
(2024)
Spatiotemporal signal space separation for regions of interest: Application for extracting neuromagnetic responses evoked by deep brain stimulation.
Human Brain Mapping
, 45
(2)
, Article e26602. 10.1002/hbm.26602.
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Abstract
Magnetoencephalography (MEG) recordings are often contaminated by interference that can exceed the amplitude of physiological brain activity by several orders of magnitude. Furthermore, the activity of interference sources may spatially extend (known as source leakage) into the activity of brain signals of interest, resulting in source estimation inaccuracies. This problem is particularly apparent when using MEG to interrogate the effects of brain stimulation on large‐scale cortical networks. In this technical report, we develop a novel denoising approach for suppressing the leakage of interference source activity into the activity representing a brain region of interest. This approach leverages spatial and temporal domain projectors for signal arising from prespecified anatomical regions of interest. We apply this denoising approach to reconstruct simulated evoked response topographies to deep brain stimulation (DBS) in a phantom recording. We highlight the advantages of our approach compared to the benchmark—spatiotemporal signal space separation—and show that it can more accurately reveal brain stimulation‐evoked response topographies. Finally, we apply our method to MEG recordings from a single patient with Parkinson's disease, to reveal early cortical‐evoked responses to DBS of the subthalamic nucleus.
| Type: | Article |
|---|---|
| Title: | Spatiotemporal signal space separation for regions of interest: Application for extracting neuromagnetic responses evoked by deep brain stimulation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/hbm.26602 |
| Publisher version: | http://dx.doi.org/10.1002/hbm.26602 |
| Language: | English |
| Additional information: | © 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | magnetoencephalography, source leakage correction, spatiotempotal signal separation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187088 |
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