Ekram, Basm;
Trueman, Ryan P;
Phillips, James B;
Ros, Helena;
Abd El-Hady, Bothaina M;
El-Gendy, Dalia M;
(2024)
Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications.
Polymer Engineering and Science
, 64
(4)
pp. 1534-1547.
10.1002/pen.26632.
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Abstract
The study aimed to develop a potential biomaterial for neuroregeneration by the electrospinning of the biocompatible polymer polyvinylidene fluoride (PVDF) with innovative functionalized boron nitride quantum dots (F-BNQDs) synthesized via green chemistry using the amino acid taurine as a functionalization. The F-BNQDs were characterized and were found to be 16–21 nm in diameter, showed good photoluminescent characteristics, and their elemental composition was confirmed by x-ray photoelectron spectroscopy, Fourier-transform infrared (FTIR), and ultraviolet spectroscopy. The PVDF with F-BNQDs was prepared at three different concentrations, and the resulting electrospun fibers were characterized by scanning electron microscopy, FTIR, thermogravimetric analysis, contact angle, biodegradation, water uptake, Schwann cell cytotoxicity, and cell behavior studies. The results of the study showed that the addition of F-BNQDs to PVDF resulted in enhanced mechanical properties, decreased contact angle, increased degradability, and water uptake. The lactate dehydrogenase assay revealed that 5% BN-PVDF had the lowest cytotoxicity. Fluroscent 4',6-diamidino-2-phenylindole (DAPI) staining showed that the increase in F-BNQD concentration up to 5% BN-PVDF enhanced cell behavior on the electrospun fibers. Therefore, the study concluded that 5% BN-PVDF would be suitable for further testing as a potential biomaterial for neuroregeneration in vivo.
| Type: | Article |
|---|---|
| Title: | Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/pen.26632 |
| Publisher version: | https://doi.org/10.1002/pen.26632 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | electrospinning, functionalized boron nitride quantum dots, PVDF, Schwann cells, taurine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187059 |
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