Liu, Hua-Bing;
Chen, Qin-Yan;
Wang, Xue-Yan;
Zhang, Lu-Juan;
Hu, Li-Ping;
Harrison, Tim J;
Wang, Chao;
(2021)
Infection with Hepatitis B Virus May Increase the Serum Concentrations of Osteopontin.
Intervirology
, 64
(3)
pp. 126-134.
10.1159/000513687.
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Abstract
BACKGROUND: Serum osteopontin (OPN) concentrations were found to be significantly increased in patients infected with hepatitis B virus (HBV) and patients with hepatocellular carcinoma (HCC). OBJECTIVE: The aim of this study was to determine the association among HCC, OPN, and HBV. METHODS: Two hundred and forty-one subjects were recruited and divided into 6 groups: healthy controls, asymptomatic HBsAg carriers, HBsAg (−) patients with other tumors, HBsAg (+) chronic liver disease patients, HBsAg (+) patients with HCC, and HBsAg (−) patients with HCC or liver cirrhosis (LC). Serum concentrations of OPN and HBsAg were measured and analyzed. RESULTS: OPN concentrations in the HBsAg (+) HCC group were significantly higher than the healthy control group and the HBsAg (−) patients with other cancers (both p = 0.0001). The OPN concentrations of the HBsAg (−) patients with HCC or LC also did not differ significantly from those of the healthy control group (p = 0.075). There is a correlation between the titer of HBsAg and concentrations of OPN in all 3 HBsAg (+) groups (all p values <0.05). CONCLUSIONS: Infection with HBV may increase the serum concentrations of OPN. The association of OPN and HCC may be not attributable to tumor development per se but, rather, to HBV infection.
| Type: | Article |
|---|---|
| Title: | Infection with Hepatitis B Virus May Increase the Serum Concentrations of Osteopontin |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1159/000513687 |
| Publisher version: | http://dx.doi.org/10.1159/000513687 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published by S. Karger AG, Basel. This is an Open Access article licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC)(http://www.karger.com/Services/OpenAccessLicense). |
| Keywords: | Hepatitis B virus, HBsAg, Osteopontin, Hepatocellular carcinoma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187004 |
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