Westensee, Isabella Nymann;
Thomsen, Karen Louise;
Mookerjee, Rajeshwar Prosad;
Städler, Brigitte;
(2024)
Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells.
Advanced Biology
, Article e2300547. 10.1002/adbi.202300547.
(In press).
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Abstract
Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.
| Type: | Article |
|---|---|
| Title: | Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adbi.202300547 |
| Publisher version: | http://dx.doi.org/10.1002/adbi.202300547 |
| Language: | English |
| Additional information: | © 2024 The Authors. Advanced Biology published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | EUK compounds, antioxidants, hepatocytes, hydrogels, reactive oxygen species |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186856 |
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