Giram, Prabhanjan S;
Wang, Julie Tzu-Wen;
Walters, Adam A;
Rade, Priyanka P;
Akhtar, Muhammad;
Han, Shunping;
Faruqu, Farid N;
... Al-Jamal, Khuloud T; + view all
(2021)
Green synthesis of methoxy-poly(ethylene glycol)-
block-poly(L-lactide-co-glycolide) copolymer
using zinc proline as a biocompatible initiator for
irinotecan delivery to colon cancer in vivo.
Biomaterials Science
, 9
(3)
pp. 795-806.
10.1039/d0bm01421d.
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Abstract
Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly (ethylene glycol)-block-poly(L-lactic-co-glycolic acid) (mPEG–PLGA). mPEG–PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140–160 nm), surface charge (∼−10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween® 80 coated NP-Ir, the Pluronic® F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery
| Type: | Article |
|---|---|
| Title: | Green synthesis of methoxy-poly(ethylene glycol)- block-poly(L-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d0bm01421d |
| Publisher version: | http://dx.doi.org/10.1039/d0bm01421d |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186705 |
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