Yatsunyk, Liliya;
Neidle, Stephen;
(2024)
On Water Arrangements in Right- and Left-Handed DNA Structures.
Molecules
, 29
(2)
, Article 505. 10.3390/molecules29020505.
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Abstract
DNA requires hydration to maintain its structural integrity. Crystallographic analyses have enabled patterns of water arrangements to be visualized. We survey these water motifs in this review, focusing on left- and right-handed duplex and quadruplex DNAs, together with the i-motif. Common patterns of linear spines of water organization in grooves have been identified and are widely prevalent in right-handed duplexes and quadruplexes. By contrast, a left-handed quadruplex has a distinctive wheel of hydration populating the almost completely circular single groove in this structure.
| Type: | Article |
|---|---|
| Title: | On Water Arrangements in Right- and Left-Handed DNA Structures |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/molecules29020505 |
| Publisher version: | https://doi.org/10.3390/molecules29020505 |
| Language: | English |
| Additional information: | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Left- and right-handed DNAs; quadruplex DNAs; crystal structures; water networks; spine of hydration; wheel of hydration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186535 |
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