Cheng, Daryl;
Calderwood, Claire;
Skyllberg, Erik;
Ainley, Adam;
(2021)
Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis.
BMJ Open Respiratory Research
, 8
(1)
, Article e000813. 10.1136/bmjresp-2020-000813.
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Abstract
BACKGROUND: Descriptions of clinical characteristics of patients hospitalised withCOVID-19, their clinical course and short-term inpatient and outpatient outcomes in deprived urban populations in the UK are still relatively sparse. We describe the epidemiology, clinical course, experience of non-invasive ventilation and intensive care, mortality and short-term sequelae of patients admitted to two large District General Hospitals across a large East London National Health Service Trust during the first wave of the pandemic. METHODS: A retrospective analysis was carried out on a cohort of 1946 patients with a clinical or laboratory diagnosis of COVID-19, including descriptive statistics and survival analysis. A more detailed analysis was undertaken of a subset of patients admitted across three respiratory units in the trust. RESULTS: Increasing age, male sex and Asian ethnicity were associated with worse outcomes. Increasing severity of chest X-ray abnormalities trended with mortality. Radiological changes persisted in over 50% of cases at early follow-up (6 weeks). Ongoing symptoms including hair loss, memory impairment, breathlessness, cough and fatigue were reported in 70% of survivors, with 39% of patients unable to return to work due to ongoing symptoms. CONCLUSIONS: Understanding the acute clinical features, course of illness and outcomes of COVID-19 will be crucial in understanding the effect of differences in risk, as well as the effectiveness of new interventions and vaccination between the successive waves of the pandemic.
| Type: | Article |
|---|---|
| Title: | Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bmjresp-2020-000813 |
| Publisher version: | http://dx.doi.org/10.1136/bmjresp-2020-000813 |
| Language: | English |
| Additional information: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| Keywords: | clinical epidemiology, imaging/CT MRI etc, non invasive ventilation, pneumonia, respiratory infection, viral infection, Age Factors, Aged, Aged, 80 and over, Alopecia, COVID-19, Cohort Studies, Cough, Dyspnea, Ethnicity, Fatigue, Female, Hospital Mortality, Humans, Intensive Care Units, London, Male, Memory Disorders, Middle Aged, Multivariate Analysis, Noninvasive Ventilation, Proportional Hazards Models, Retrospective Studies, Return to Work, Risk Factors, SARS-CoV-2, Severity of Illness Index, Sex Factors, Post-Acute COVID-19 Syndrome |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186256 |
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