Semyachkina-Glushkovskaya, O;
Fedosov, I;
Zaikin, A;
Ageev, V;
Ilyukov, E;
Myagkov, D;
Tuktarov, D;
... Kurths, J; + view all
(2023)
Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice.
Biomedical Optics Express
, 15
(1)
pp. 44-58.
10.1364/BOE.505618.
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Abstract
In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation in the peripheral lymphatics, we demonstrate stronger effects of photobiomodulation (PBM) on the brain’s drainage system in sleeping vs. awake animals. Using the Pavlovian instrumental transfer probe and the 2-objects-location test, we found that the 10-day course of PBM during sleep vs. wakefulness promotes improved learning and spatial memory in mice. For the first time, we present the technology for PBM under electroencephalographic (EEG) control that incorporates modern state of the art facilities of optoelectronics and biopotential detection and that can be built of relatively cheap and commercially available components. These findings open a new niche in the development of smart technologies for phototherapy of brain diseases during sleep.
| Type: | Article |
|---|---|
| Title: | Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.505618 |
| Publisher version: | http://dx.doi.org/10.1364/boe.505618 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185742 |
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