Porta, EOJ;
Steel, PG;
(2023)
Activity-based protein profiling: A graphical review.
Current Research in Pharmacology and Drug Discovery
, 5
, Article 100164. 10.1016/j.crphar.2023.100164.
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Abstract
Activity-based protein profiling (ABPP) is a chemoproteomic technology that employs small chemical probes to directly interrogate protein function within complex proteomes. Since its initial application almost 25 years ago, ABPP has proven to be a powerful and versatile tool for addressing numerous challenges in drug discovery, including the development of highly selective small-molecule inhibitors, the discovery of new therapeutic targets, and the illumination of target proteins in tissues and organisms. This graphical review provides an overview of the rapid evolution of ABPP strategies, highlighting the versatility of the approach with selected examples of its successful application.
| Type: | Article |
|---|---|
| Title: | Activity-based protein profiling: A graphical review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.crphar.2023.100164 |
| Publisher version: | http://dx.doi.org/10.1016/j.crphar.2023.100164 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by Elsevier B.V. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Activity-based protein profiling, Activity-based probes, Affinity-based probes, Chemical probes, Chemoproteomics, Drug discovery, Mass spectrometry, Target discovery |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185700 |
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