Booth, Rhonda; (2021) Agenesis of the Corpus Callosum: Information for families and individuals affected by disorders of the Corpus Callosum. Corpal: DCC &. Aicardi Syndrome UK

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Abstract

Agenesis of the corpus callosum describes the condition in which the corpus callosum failed to develop, either partially or completely. In complete agenesis, the corpus callosum is completely absent and did not develop. In partial agenesis (also referred to as hypogenesis), the corpus callosum began to develop but something stopped it from growing in the usual way. As the corpus callosum generally develops from front to back, the part of the corpus callosum present is usually at the front, but this is not always the case. A smaller portion of the corpus callosum may remain, or it could be present but smaller and thinner than usual. If all of the corpus callosum forms, but is unusually thin, this may be referred to as hypoplasia of the corpus callosum. It is not clear whether the nerve fibres in a thin corpus callosum will be fully functional and just fewer in number, or whether they are both dysfunctional and limited in number. Another rare condition is hyperplasia, which describes an unusual thickening of the corpus callosum. If the corpus callosum developed, but is malformed or incomplete in some way, it can be described under the broad term dysgenesis of the corpus callosum. Complete agenesis, partial agenesis, hypoplasia and dysgenesis all come under the umbrella term disorders of the corpus callosum.

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