Park, Hee Kyung;
Choi, Seong Hye;
Kim, SeonMyeong;
Park, Ukeob;
Kang, Seung Wan;
Jeong, Jee Hyang;
Moon, So Young;
... Park, Yoo Kyoung; + view all
(2022)
Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia.
Frontiers in Aging Neuroscience
, 14
, Article 892590. 10.3389/fnagi.2022.892590.
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Abstract
Quantitative electroencephalography (QEEG) has proven useful in predicting the response to various treatments, but, until now, no study has investigated changes in functional connectivity using QEEG following a lifestyle intervention program. We aimed to investigate neurophysiological changes in QEEG after a 24-week multidomain lifestyle intervention program in the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN). Participants without dementia and with at least one modifiable dementia risk factor, aged 60–79 years, were randomly assigned to the facility-based multidomain intervention (FMI) (n = 51), the home-based multidomain intervention (HMI) (n = 51), and the control group (n = 50). The analysis of this study included data from 44, 49, and 34 participants who underwent EEG at baseline and at the end of the study in the FMI, HMI, and control groups, respectively. The spectrum power and power ratio of EEG were calculated. Source cortical current density and functional connectivity were estimated by standardized low-resolution brain electromagnetic tomography. Participants who received the intervention showed increases in the power of the beta1 and beta3 bands and in the imaginary part of coherence of the alpha1 band compared to the control group. Decreases in the characteristic path lengths of the alpha1 band in the right supramarginal gyrus and right rostral middle frontal cortex were observed in those who received the intervention. This study showed positive biological changes, including increased functional connectivity and higher global efficiency in QEEG after a multidomain lifestyle intervention. Clinical trial registration: [https://clinicaltrials.gov/ct2/show/NCT03980392] identifier [NCT03980392].
| Type: | Article |
|---|---|
| Title: | Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2022.892590 |
| Publisher version: | http://dx.doi.org/10.3389/fnagi.2022.892590 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Neurosciences, Neurosciences & Neurology, cognitive impairment, biomarkers, quantitative electroencephalography, dementia, multidomain intervention, MILD COGNITIVE IMPAIRMENT, INTERHEMISPHERIC EEG COHERENCE, ALZHEIMERS-DISEASE, QUANTITATIVE EEG, ALPHA RHYTHMS, RESTING-STATE, POWER, RIVASTIGMINE, CORRELATE, NETWORK |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185659 |
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