Ramin, Elham;
Cardillo, Antonio Gaetano;
Liebers, Reinhard;
Schmölder, Johannes;
Von Lieres, Eric;
Van Molle, Wim;
Niebel, Bastian;
... Gernaey, Krist V; + view all
(2024)
Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities.
Current Opinion in Chemical Engineering
, 43
, Article 100998. 10.1016/j.coche.2023.100998.
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Abstract
This review highlights the importance of model-based approaches in accelerating vaccine manufacturing process development. The challenges of scaling up from laboratory to commercial processes are addressed through the adoption of Process Analytical Technology frameworks and Quality by Design principles. The application of various modeling approaches beyond downstream and upstream processes in vaccine production is discussed in detail. These in silico process simulation approaches enable deeper understanding of manufacturing dynamics, identification of critical process parameters, and the development of well-defined design spaces, ultimately leading to accelerated vaccine development and improved product quality. The authors stress the significance of an integrated modeling platform for vaccine manufacturing, exemplified by the Inno4Vac project. This initiative seeks to develop a comprehensive computational platform for vaccine manufacturing and stability testing, with a particular focus on stakeholder engagement and collaboration with regulatory bodies to ensure the acceptance and implementation of the platform.
| Type: | Article |
|---|---|
| Title: | Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.coche.2023.100998 |
| Publisher version: | http://dx.doi.org/10.1016/j.coche.2023.100998 |
| Language: | English |
| Additional information: | Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185289 |
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