Morahan, Ashley James;
(2024)
Technical Evaluation of the World's First Simultaneous Clinical SPECT-MRI Imaging System.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
This thesis outlines the analysis and evolution of a SPECT insert system designed for simultaneous use within a clinical MRI. The INSERT (INtegrated SPECT/MRI for Enhanced stratification of brain tumours in Radio-chemoTherapy) is the world’s first clinical SPECT-MRI brain imaging system based on scintillation detectors with a SiPM readout. This work demonstrates its use as a stand-alone SPECT scanner and a simultaneous SPECT-MRI. The use of a clinical SPECT-MRI is carried out here for the first time. The development of this novel technology is outlined, and its applications were investigated to establish the first-in-man study. The stand-alone SPECT scanner is evaluated, and its limitations are addressed through phantom studies in which techniques such as statistical image reconstruction, Monte Carlo simulations, and deep learning are deployed to solve issues with the SPECT design and performance. The system is used within a clinical environment and compared to established SPECT scanners to evaluate its feasibility as a clinical scanner. Finally, the INSERT is installed within an MRI and evaluated as a simultaneous clinical system. Hardware upgrades and development of specialised MRI imaging sequences allowed both systems to operate in unison. This body of work establishes the possibility of a simultaneous clinical SPECT-MRI. It looks to develop the technology further through patient trials and continued improvements of the clinical system.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Technical Evaluation of the World's First Simultaneous Clinical SPECT-MRI Imaging System |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185274 |
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