Moonen, Justine EF;
Haan, Renée;
Bos, Isabelle;
Teunissen, Charlotte;
Van de Giessen, Elsmarieke;
Tomassen, Jori;
Den Braber, Anouk;
... Van der Flier, Wiesje M; + view all
(2023)
Contributions of amyloid beta and cerebral small vessel disease in clinical decline.
Alzheimer's & Dementia
10.1002/alz.13607.
(In press).
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Abstract
INTRODUCTION: We assessed whether co-morbid small vessel disease (SVD) has clinical predictive value in preclinical or prodromal Alzheimer's disease. // METHODS: In 1090 non-demented participants (65.4 ± 10.7 years) SVD was assessed with magnetic resonance imaging and amyloid beta (Aβ) with lumbar puncture and/or positron emission tomography scan (mean follow-up for cognitive function 3.1 ± 2.4 years). // RESULTS: Thirty-nine percent had neither Aβ nor SVD (A–V–), 21% had SVD only (A–V+), 23% Aβ only (A+V–), and 17% had both (A+V+). Pooled cohort linear mixed model analyses demonstrated that compared to A–V– (reference), A+V– had a faster rate of cognitive decline. Co-morbid SVD (A+V+) did not further increase rate of decline. Cox regression showed that dementia risk was modestly increased in A–V+ (hazard ratio [95% confidence interval: 1.8 [1.0–3.2]) and most strongly in A+ groups. Also, mortality risk was increased in A+ groups. // DISCUSSION: In non-demented persons Aβ was predictive of cognitive decline, dementia, and mortality. SVD modestly predicts dementia in A–, but did not increase deleterious effects in A+.
| Type: | Article |
|---|---|
| Title: | Contributions of amyloid beta and cerebral small vessel disease in clinical decline |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.13607 |
| Publisher version: | http://dx.doi.org/10.1002/alz.13607 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License,https://creativecommons.org/licenses/by-nc-nd/4.0/, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Amyloid beta, cognitive decline, dementia, mortality, small vessel disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185211 |
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