Oltra, Javier;
Habich, Annegret;
Schwarz, Christopher G;
Nedelska, Zuzana;
Przybelski, Scott A;
Inguanzo, Anna;
Diaz-Galvan, Patricia;
... Ferreira, Daniel; + view all
(2023)
Sex differences in brain atrophy in dementia with Lewy bodies.
Alzheimer's & Dementia
10.1002/alz.13571.
(In press).
Preview |
Text
Barkhof_Alzheimer s Dementia-2023-Oltra-Sex differences in brain atrophy in dementia with Lewy bodies.pdf Download (1MB) | Preview |
Abstract
INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). // METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). // RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. // DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75.
| Type: | Article |
|---|---|
| Title: | Sex differences in brain atrophy in dementia with Lewy bodies |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.13571 |
| Publisher version: | http://dx.doi.org/10.1002/alz.13571 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, https://creativecommons.org/licenses/by-nc/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | Atrophy; dementia with Lewy bodies; magnetic resonance imaging; sex differences |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10184529 |
Archive Staff Only
 |
View Item |
