Tong, Steven YC;
Mora, Jocelyn;
Bowen, Asha C;
Cheng, Matthew P;
Daneman, Nick;
Goodman, Anna L;
Heriot, George S;
... Davis, Joshua S; + view all
(2022)
The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe.
Clinical Infectious Diseases
, 75
(11)
pp. 2027-2034.
10.1093/cid/ciac476.
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Abstract
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. The limited evidence base partly results from clinical trials for SAB infections being difficult to complete at scale using traditional clinical trial methods. Here we provide the rationale and framework for an adaptive platform trial applied to SAB infections. We detail the design features of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial that will enable multiple questions to be answered as efficiently as possible. The SNAP trial commenced enrolling patients across multiple countries in 2022 with an estimated target sample size of 7000 participants. This approach may serve as an exemplar to increase efficiency of clinical trials for other infectious disease syndromes.
| Type: | Article |
|---|---|
| Title: | The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/cid/ciac476 |
| Publisher version: | https://doi.org/10.1093/cid/ciac476 |
| Language: | English |
| Additional information: | © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Staphylococcus aureus; bacteremia; bloodstream infection; randomized controlled trial; adaptive platform |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10184133 |
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