Genoud, Vassilis;
Kinnersley, Ben;
Brown, Nicholas F;
Ottaviani, Diego;
Mulholland, Paul;
(2023)
Therapeutic Targeting of Glioblastoma and the Interactions with Its Microenvironment.
Cancers
, 15
(24)
, Article 5790. 10.3390/cancers15245790.
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Abstract
Glioblastoma (GBM) is the most common primary malignant brain tumour, and it confers a dismal prognosis despite intensive multimodal treatments. Whilst historically, research has focussed on the evolution of GBM tumour cells themselves, there is growing recognition of the importance of studying the tumour microenvironment (TME). Improved characterisation of the interaction between GBM cells and the TME has led to a better understanding of therapeutic resistance and the identification of potential targets to block these escape mechanisms. This review describes the network of cells within the TME and proposes treatment strategies for simultaneously targeting GBM cells, the surrounding immune cells, and the crosstalk between them.
| Type: | Article |
|---|---|
| Title: | Therapeutic Targeting of Glioblastoma and the Interactions with Its Microenvironment |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/cancers15245790 |
| Publisher version: | https://doi.org/10.3390/cancers15245790 |
| Language: | English |
| Additional information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Glioblastoma (GBM); heterogeneity; tumour microenvironment (TME); myeloid cells; microglia; tumour associated macrophages (TAMs); therapeutic targeting |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10183856 |
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