Ndlovu, Lerato N;
Peetluk, Lauren;
Moodley, Sashen;
Nhamoyebonde, Shepherd;
Ngoepe, Abigail T;
Mazibuko, Matilda;
Khan, Khadija;
... Leslie, Alasdair; + view all
(2020)
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.
Frontiers in Immunology
, 11
, Article 1872. 10.3389/fimmu.2020.01872.
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Abstract
Tuberculosis remains a leading cause of death globally despite curative treatment, partly due to the difficulty of identifying patients who will not respond to therapy. Simple host biomarkers that correlate with response to drug treatment would facilitate improvement in outcomes and the evaluation of novel therapies. In a prospective longitudinal cohort study, we evaluated neutrophil count and phenotype at baseline, as well as during TB treatment in 79 patients [50 (63%) HIV-positive] with microbiologically confirmed drug susceptible TB undergoing standard treatment. At time of diagnosis, blood neutrophils were highly expanded and surface expression of the neutrophil marker CD15 greatly reduced compared to controls. Both measures changed rapidly with the commencement of drug treatment and returned to levels seen in healthy control by treatment completion. Additionally, at the time of diagnosis, high neutrophil count, and low CD15 expression was associated with higher sputum bacterial load and more severe lung damage on chest x-ray, two clinically relevant markers of disease severity. Furthermore, CD15 expression level at diagnosis was associated with TB culture conversion after 2 months of therapy (OR: 0.14, 95% CI: 0.02, 0.89), a standard measure of early TB treatment success. Importantly, our data was not significantly impacted by HIV co-infection. These data suggest that blood neutrophil metrics could potentially be exploited to develop a simple and rapid test to help determine TB disease severity, monitor drug treatment response, and identify subjects at diagnosis who may respond poorly to treatment.
| Type: | Article |
|---|---|
| Title: | Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2020.01872 |
| Publisher version: | https://doi.org/10.3389/fimmu.2020.01872 |
| Language: | English |
| Additional information: | Copyright © 2020 Ndlovu, Peetluk, Moodley, Nhamoyebonde, Ngoepe, Mazibuko, Khan, Karim, Pym, Maruri, Moosa, van der Heijden, Sterling and Leslie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, tuberculosis biomarker, neutrophil phenotype, blood neutrophil count, tuberculosis treatment outcome, tuberculosis disease severity, MYCOBACTERIUM-TUBERCULOSIS INFECTION, PULMONARY TUBERCULOSIS, G-CSF, CELLS, GRANULOCYTES, DIAGNOSIS, ADHESION, ANTIGEN, ACTIVATION, BIOMARKERS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10183787 |
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