Di Chiara, C;
Barbieri, E;
Chen, YX;
Visonà, E;
Cavagnis, S;
Sturniolo, G;
Parca, A;
... Cantarutti, A; + view all
(2023)
Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19.
Acta Paediatrica, International Journal of Paediatrics
, 112
(12)
pp. 2563-2571.
10.1111/apa.16966.
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Abstract
Aim: Children have largely been unaffected by severe COVID-19 compared to adults, but data suggest that they may have experienced new conditions after developing the disease. We compared outcomes in children who had experienced COVID-19 and healthy controls. / Methods: A retrospective nested cohort study assessed the incidence rate of new-onset conditions after COVID-19 in children aged 0–14 years. Data were retrieved from an Italian paediatric primary care database linked to Veneto Region registries. Exposed children with a positive nasopharyngeal swab were matched 1:1 with unexposed children who had tested negative. Conditional Cox regression was fitted to estimate the adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for the exposure and outcome associations after adjusting for covariates. / Results: We compared 1656 exposed and 1656 unexposed children from 1 February 2020 to 30 November 2021. The overall excess risk for new-onset conditions after COVID-19 was 78% higher in the exposed than unexposed children. We found significantly higher risks for some new conditions in exposed children, including mental health issues (aHR 1.8, 95% CI 1.1–3.0) and neurological problems (aHR 2.4, 95% CI 1.4–4.1). / Conclusion: Exposed children had a 78% higher risk of developing new conditions of interest after COVID-19 than unexposed children.
| Type: | Article |
|---|---|
| Title: | Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19 |
| Location: | Norway |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/apa.16966 |
| Publisher version: | https://doi.org/10.1111/apa.16966 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | COVID-19, new-onset conditions, paediatric patients, population-based study, real-world evidence, Adult, Humans, Child, COVID-19, Retrospective Studies, Cohort Studies, Incidence, Italy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10183323 |
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