Hernandez-Resendiz, S;
Prakash, A;
Loo, SJ;
Semenzato, M;
Chinda, K;
Crespo-Avilan, GE;
Dam, LC;
... Hausenloy, DJ; + view all
(2023)
Targeting mitochondrial shape: at the heart of cardioprotection.
Basic Research in Cardiology
, 118
(1)
, Article 49. 10.1007/s00395-023-01019-9.
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Abstract
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia-reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI.
| Type: | Article |
|---|---|
| Title: | Targeting mitochondrial shape: at the heart of cardioprotection |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00395-023-01019-9 |
| Publisher version: | https://doi.org/10.1007/s00395-023-01019-9 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Acute myocardial infarction, Acute myocardial ischemia–reperfusion injury, Cardioprotection, Cardiovascular diseases, Heart failure, Mitochondrial morphology, Humans, Myocardium, Myocardial Infarction, Heart Failure, Myocytes, Cardiac, Mitochondria |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10182471 |
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