Bettinger, Jesse S;
Friston, Karl J;
(2023)
Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality.
Neuroscience & Biobehavioral Reviews
, 155
, Article 105459. 10.1016/j.neubiorev.2023.105459.
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Abstract
Bettinger, J. S., K. J. Friston. Conceptual Foundations of Physiological Regulation incorporating the Free Energy Principle & Self-Organized Criticality. NEUROSCI BIOBEHAV REV 23(x) 144-XXX, 2022. Since the late nineteen-nineties, the concept of homeostasis has been contextualized within a broader class of "allostatic" dynamics characterized by a wider-berth of causal factors including social, psychological and environmental entailments; the fundamental nature of integrated brain-body dynamics; plus the role of anticipatory, top-down constraints supplied by intrinsic regulatory models. Many of these evidentiary factors are integral in original descriptions of homeostasis; subsequently integrated; and/or cite more-general operating principles of self-organization. As a result, the concept of allostasis may be generalized to a larger category of variational systems in biology, engineering and physics in terms of advances in complex systems, statistical mechanics and dynamics involving heterogenous (hierarchical/heterarchical, modular) systems like brain-networks and the internal milieu. This paper offers a three-part treatment. 1) interpret "allostasis" to emphasize a variational and relational foundation of physiological stability; 2) adapt the role of allostasis as "stability through change" to include a "return to stability" and 3) reframe the model of homeostasis with a conceptual model of criticality that licenses the upgrade to variational dynamics.
| Type: | Article |
|---|---|
| Title: | Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neubiorev.2023.105459 |
| Publisher version: | https://doi.org/10.1016/j.neubiorev.2023.105459 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by Elsevier Ltd. under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Physiological regulation, Homeostasis, Allostasis, Variational systems, Free energy principle, Criticality, Griffiths region, Complex adaptive systems, Dynamic stability, Metastability, Control theory, Neuro-immunology, Computational psychiatry, Resilience |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10182419 |
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