Lupi, E;
Gaviraghi, M;
Rancati, S;
Palesi, F;
Grussu, F;
Battiston, M;
Tur, C;
... Wheeler-Kingshott, CAMG; + view all
(2023)
Myelin quantification in Magnetic Resonance Imaging.
In:
Eighth National Congress of Bioengineering – Proceedings 2023.
Associazione Gruppo Nazionale Bioingegneria: Milan, Italy.
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Abstract
We can monitor the progression of demyelination by quantifying parameters sensitive to myelin in vivo using magnetic resonance imaging (MRI). g-ratio is an index used to monitor the myelin damage; here we developed a method to calculate g-ratio maps from different myelin-sensitive imaging techniques, i.e., quantitative magnetization transfer (qMT), considered as gold standard, and the T1W/T2W ratio. We compared the clinical sensitivity of the two methods, in a cohort of multiple sclerosis (MS) patients. Both approaches showed a similar trend of myelin damage in pathological subjects.
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